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Literature summary extracted from

  • Helske, S.; Syvaeranta, S.; Lindstedt, K.A.; Lappalainen, J.; Oeoerni, K.; Maeyraenpaeae, M.I.; Lommi, J.; Turto, H.; Werkkala, K.; Kupari, M.; Kovanen, P.T.
    Increased Expression of Elastolytic Cathepsins S, K, and V and Their Inhibitor Cystatin C in Stenotic Aortic Valves (2006), Arterioscler. Thromb. Vasc. Biol., 26, 1791-1798.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.22.43 medicine studies on the role of cathepsin V and cystatin C in the pathophysiology aortic stenosis Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.43 cystatin C endogenous inhibitor of cathepsin V analyzed, expression of cystatin C increased in stenotic valves, cystatin C protein particularly found in areas with infiltrates of inflammatory cells Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.43 Homo sapiens O60911
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.43 aorta expression in aorta valve, control valves and stenotic valves analyzed Homo sapiens
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3.4.22.43 aorta endothelium cathepsin V localized to endothelial cells in areas rich of neovascularization Homo sapiens
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Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.22.43 additional information
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 expression of cathepsin V studied by RT-PCR and immunohistochemistry, cathepsin activity in aortic valves quantified by fluorometric microassay, increased mRNA expression and high activity of cathepsin V in stenotic valves observed, association of cathepsin V and the inhibitor cystatin C with calcific aortic valve disease determined, participation in adverse extracellular matrix remodelling of stenotic aortic valves suggested Homo sapiens
3.4.22.43 additional information
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 expression of cathepsin V studied by RT-PCR and immunohistochemistry, cathepsin activity quantified by fluorometric microassay, intense association of cathepsin V with neovessels of the stenotic aortic valves reveals a role in neovascularization of the valves Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.43 Z-Phe-Arg-7-amido-4-methylcoumarin + H2O role of cathepsis V and the endogenous inhibitor cystatin C in adverse extracellular matrix remodeling of stenotic aortic valves analyzed Homo sapiens Z-Phe-Arg + 7-amino-4-methylcoumarin
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